Addiction

Background: Long-term alcohol use is known to harm brain functioning in adolescence. In the central nervous system, the effects of alcohol are particularly mediated by alterations in GABAergic neurotransmission. Combining simultaneous...

Alcohol and nicotine are two of the most frequently abused drugs, with their comorbidity well described. Previous data show that chronic exposure to nicotine upregulates high-affinity nicotinic acetylcholine receptors (nAChRs) in several...

Nicotine is the addictive component of conventional cigarettes. E-cigarettes are available in a range of nicotine strengths. Those that contain nicotine were deemed recently to be subject to regulation by the US Food and Drug Administration...

12- to 17-year-olds in the US are now far less likely to misuse alcohol, nicotine and illegal drugs. The same age group is also less prone to delinquent behaviours, such as stealing and fighting than the generation before. This is according...

Lesbian, gay, and bisexual (LGB) individuals report higher levels of problematic alcohol and substance use than their heterosexual peers. This disparity is linked to the experience of LGB-specific stressors, termed minority stress...

In the US, less than 10% of adults with co-occurring mental health problems and substance use disorders get treatment for both. 50% do not receive treatment for either. This highlights the vast discrepancy between the prevalence of co...